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Understanding perceptions of HIV-positive people taking malaria treatment

Start date: 1 Jul 2011

[Project summary in Français / Português]

Scientific title: Qualitative study to understand perceptions of malaria and malaria treatment amongst HIV positive individuals enrolled in an antimalarial drug trial in Muheza, Tanzania

Latest on this research

[Français / Português]

Key findings include that HIV-positive people saw malaria as potentially more harmful to them due to their HIV status. However, this did not seem to translate into an increased effort to prevent malaria, as the disease was often seen as ‘unavoidable’. 

Our results suggest that health workers’ advice may play an important role in encouraging patients to take both malaria and HIV treatment simultaneously. Overall, patients felt that taking antimalarial and antiretroviral treatment at the same time was unproblematic and generally reported  a high adherence to medication. Nevertheless, some patients perceived the combined treatment as too strong and said that they took the different drugs at different times to avoid harm to the body.

We have found that the social and material dynamics of the trial may have influenced participants’ attitudes towards taking both treatments simultaneously.  They perceived the trial as a ‘project’ that provided enhanced care to those participating.

Overall, this study indicates that the dynamics between health workers, patients and broader social and economic conditions influence patients’ perceptions of taking treatment for both HIV and malaria at the same time, as well as adherence to treatment regimes.  Further support is needed to help HIV-positive people manage the perceived risks around contracting malaria and encourage them to prevent malaria infection. Managing cases of co-infection may also be improved if health workers communicate better with patients about the instructions to take treatment in the context of their daily lives.

In 2012 the research team held several dissemination and discussion events with hospital staff, trial staff and local researchers in Tanga region.

Scroll down for related resources, including peer-reviewed publications.

What did we know before this research?

In many malaria-endemic countries HIV/AIDS continues to spread, therefore an increasing number of patients need treatment for both infections at the same time.

The WHO and ministries of health in many endemic countries recommend the use of artemisinin-based combination therapy (ACT) for malaria and antiretroviral combination treatments (ART) for HIV/AIDS.

Such treatments have become increasingly available and research is being conducted into the clinical implications of taking ACT and ART concomitantly. 

What does this study add?

Thus far, social science research has focused either on people’s perceptions and experiences of HIV and antiretroviral drugs, or of malaria and antimalarial drugs. A gap remains in knowledge of how HIV-positive people understand and experience malaria and its treatment, as well as how these may affect their behaviour to prevent and seek treatment.

Understanding these perceptions better will help identify ways to improve the management of cases of HIV and malaria co-infection.

This is a qualitative study with participants of the InterACT trial, other HIV-positive people and members of trial and hospital staff. The aim of the study is to explore their perceptions of taking malaria treatment at the same time as anti-retroviral therapy (ART) for HIV infection.  We also explored how participants experienced and understood their engagement in the InterACT trial.

The research team

Principal Investigators:

  • Dr. Lasse Vestergaard, University of Copenhagen


  • Dr Clare Chandler, London School of Hygiene & Tropical Medicine


  • Dr. Martha Lemnge, Director, National Institute of Medical Research, Tanga Centre, Tanga, Tanzania

Other Investigators

  • Dr. Peter Mangesho, National Institute of Medical Research, Amani Centre, Muheza, Tanzania
  • Ms Joanna Reynolds, London School of Hygiene & Tropical Medicine

Related Publications

'… in the project they really care for us': meaning and experiences of participating in a clinical study of first-line treatment for malaria and HIV in Tanzanian adults.

Joanna Reynoldsa, Peter Mangeshob, Martha M. Lemngec, Lasse S. Vestergaardde & Clare I.R. Chandlera  |  Published
Global Public Health

Exploring meaning of participation in a clinical trial in a developing country setting: implications for recruitment

Joanna Reynolds, Peter Mangesho, Lasse S Vestergaard, Clare Chandler  |  Published
Trails Journal

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