The PRIME trial: Improving health centres to reduce childhood malaria in Uganda

[Project summary in Français / Português]

Scientific title: Evaluating the impact of an intervention implemented in public health centres on management of malaria and health outcomes of children using a cluster-randomised design in Tororo, Uganda

PROCESS: Evaluating how the PRIME intervention worked in practice

[Project summary in Français / Português]

Scientific title: What is the process, context and impact of the PRIME health facility intervention and how can this explain the findings of the trial’s endpoints?  

Use of rapid diagnostic tests to improve malaria treatment in the community in Uganda

[Project summary in Français / Português]

Scientific title: The role and cost-effectiveness of rapid diagnostic tests in home-based management of malaria using artemether-lumefantrine: a comparative study in two areas of high and low malaria transmission in rural Uganda

Introducing rapid diagnostic tests in drug shops to improve the targeting of malaria treatment

[Project summary in Français / Português]

Scientific title: Introducing rapid diagnostic tests (RDTs) into the public and private health sectors in Uganda: a randomised trial to evaluate impact on antimalarial drug use

Perceptions and impact of introducing rapid diagnostic tests in drug shops

[Project summary in Français / Português]

Scientific title: Evaluation of the referral system implemented in registered drug shops, and impact on the public health systems in Uganda.

IMPACT 2: Evaluating policies in Tanzania to improve malaria diagnosis and treatment

[Project summary in Français / Português]

Scientific title: IMPACT 2: Monitoring Interventions to Improve ACT Access and Targeting 

Effectiveness and cost-effectiveness of interventions to support the introduction of malaria rapid diagnostic tests in Cameroon

[Project summary in Français / Português]

Scientific title: AEffectiveness and cost-effectiveness analysis of provider interventions to improve health worker practice in providing treatment for uncomplicated malaria in Cameroon

Costs and effects of strategies to improve malaria diagnosis and treatment in Nigeria

[Project summary in Français / Português]

Scientific title: A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria

Strategies for expanding access to quality malaria diagnosis in south-central Asia where malaria incidence is low

[Project summary in Français / Português]

Scientific title: An examination of ACT strategy in south-central Asia on P. falciparum malaria in a context where P. vivax is the major species.

Trusting rapid diagnostic tests in Zanzibar

[Project summary in Français / Português]

Scientific title: Effectiveness of Malaria Rapid Diagnostic Tests in fever patients attending primary health care facilities in Zanzibar

Identifying causes of fever in children under five in Zanzibar

[Project summary in Français / Português]

Scientific title: Infectious disease aetiologies of uncomplicated febrile illness in children <5 years of age in rural Zanzibar

Restricting ACT drugs to patients with positive rapid diagnostic test results

[Project summary in Français / Português]

Scientific title: Effects of Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial (RDT-ACT)

Targeting ACT drugs: the TACT trial

[Project summary in Français / Português]

Scientific title: A cluster-randomised trial of health worker and community interventions to improve adherence to national guidelines for the use of ACTs in Tanzania

InterACT: Interactions between malaria and HIV drugs in a malaria endemic area

[Project summary in Français / Português]

Scientific title: Interactions between artemisinin-based combination treatment for malaria and antiretrovirals for HIV/AIDS in co-infected patients in Muheza, Tanzania

Understanding perceptions of HIV-positive people taking malaria treatment

[Project summary in Français / Português]

Scientific title: Qualitative study to understand perceptions of malaria and malaria treatment amongst HIV positive individuals enrolled in an antimalarial drug trial in Muheza, Tanzania

The ACTia trial: Safety of repeated drug use in children

[Project summary in Français / Português]

Scientific title: Programmatic implementation of ACTs in Malawi: Safety and effectiveness of combination therapies with repeated treatments for uncomplicated P. falciparum malariaover a three-year period

How perceptions of malaria medication affect adherence

[Project summary in Français / Português]

Scientific title: Qualitative study on antimalarial drug use in the context of perceptions of ACTs and intra-household decision making in the Chikhwawa district of Malawi

Malaria indicator survey to support national control programmes

[Project summary in Français / Português]

Scientific title: Determining sub-national intervention coverage and malaria impact estimates in young children and older age groups using a continuous Malaria Indicator Survey in Chikhwawa district, Malawi

Collating drug safety data from ACT Consortium studies

[Project summary in Français / Português]

Scientific title: A Drug Safety Database for the ACT Consortium

Interactions between malaria and HIV drugs in people living with HIV

[Project summary in Français / Português]

Scientific title: Interactions between the antimalarial combination artemether/lumefantrine and antiretroviral therapy including nevirapine or lopinavir/ritonavir in HIV-infected adults

Collecting safety data in antimalarial drug trials

[Project summary in Français / Português]

Scientific title: Strategies for optimizing the accurate elicitation of patient-reported data relating to drug safety 

Analysing the quality and authenticity of ACT drugs

[Project summary in Français / Português]

Scientific title: Development of standardized methods for efficient representative sampling of drugs for laboratory analysis to obtain robust estimates of the frequency of counterfeit, substandard and degraded artemisinin containing drugs in countries.

How the use of rapid diagnostic tests influences clinicians decision to prescribe ACTs

[Project summary in Français / Português]

Scientific title: Social and economic evaluations of the introduction of rapid diagnostic tests for Malaria alongside a randomised controlled trial in rural health facilities in Ghana 

Identifying non-malaria illnesses that cause fever

[Project summary in Français / Português]

Scientific title: Identifying non-malarial causes of fever in outpatients from malarious areas in different geographic locations: CONFIT and CONFIA studies

Access and quality of malaria diagnosis and treatment in South-East Asia

[Project summary in Français / Português]

Scientific titles:

1. Good Use of ACTs and Rapid Diagnostic Tests (RDTs) in Cambodia  (GUARD)
2. Village Malaria Worker Access and Treatment study (VIMWAT)
3. Drug quality and antimalarial drug resistance - Tracking Resistance to Artemisinins Collaboration (TRAC)